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Post-Doctoral Research Fellow – Adoptive T Cell Immunotherapy

Fred Hutchinson Cancer Research Center
Seattle, WA

A postdoctoral fellow is sought to join the lab of Aude Chapuis within the Program in Immunology in the Clinical Research Division at Fred Hutchinson Cancer Research Center. The post-doctoral research fellow will work on independent and collaborative projects developing adoptive T cell immunotherapy for hematologic and solid tumor malignancies. The successful applicant will employ strategies for cloning T cell receptors and genetic modification of human T cells with TCRs specific for antigens expressed by malignancies. In vitro studies using human T cells and in vivo murine models will be used to develop and test novel T cell therapies. The research fellow will perform correlative studies to evaluate the transfer, persistence and function of antigen-specific T cells in human clinical trials of adoptive T cell immunotherapy. The position will involve molecular work with PCR, cloning, vector design, as well as cell culture, cell sorting, flow cytometry, intercellular staining, transfections, ELISPOT and Chromium Release Assays.

The Program in Immunology is a leader in the development and clinical application of adoptive immunotherapy using genetically modified T cells and is committed to the advancement of this approach. The post-doctoral research fellow may also participate in the laboratory evaluation of ongoing clinical trials involving engineering of peripheral blood stem cell grafts for improved allogeneic hematopoietic stem cell transplantation outcomes, and in the development of future immunotherapy strategies.

This is a full-time position with a salary based on the NIH scale and excellent benefits.

To be considered, the successful applicant must have:

  • A PhD and/or MD in biological science
  • Strong research background with robust skills in molecular biology and cellular immunology, including experience in cloning strategies, flow cytomtery, and cell signaling based assays
  • Experience in analysis of T Cell Receptor (TCR) signaling pathways and lentiviral modification of T cells is strongly desired
  • Strong motivation and drive to establish a career as a future independent investigator

For more information, and to apply, please visit http://www.fredhutch.org/job/7482. Inquiries can also be sent to Dr. Jessica Huszar at jhuszar@fredhutch.org.

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Important Dates

  • Abstracts

    Deadline to Request Edits to Abstracts March 1, 2016
    Abstract Acceptance & Schedule March 11, 2016

  • Travel Awards

    Travel Award Notifications March 11, 2016

  • Registration

    Registration Opens December 16, 2015
    Early Registration Deadline March 30, 2016
    Late Registration Deadline May 12, 2016

  • Housing

    Deadline for Discounted Rates April 22, 2016

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1:45 PM – 2:30 PM
EXHIBITOR WORKSHOP ROOM 2
Thermo Fisher Scientific

Presenter:

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Presenter:

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Presenter:

Multilaser flow cytometers with the capacity for simultaneous measurement of sufficient targets for immunological analysis
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Fast and Easy Isolation of Highly Pure Unique Immune Cell Subsets Using EasySep™ Release

12:30 PM-1:15 PM
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Presenters:

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11:15 AM - 12:00 PM
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For a long time, studying the adaptive immune system has been central in the design of therapeutics. New insights indicate that complement activation also regulates fundamental processes of the cell, such as metabolic activity and homeostasis. It also serves as a nexus for the interaction with other effector systems. Specifically, an intracellular complement/NLRP3 inflammasome crosstalk emerges as critical for normal IFN-g secretion by T cells. Advancing insights have not only shown that innate immune regulators are present  but are also key in directing immunological responses. This is of great significance to our understanding of the biology of immune cells and  immune system evolution. It also helps explain why targeting just one arm of the immune system is insufficient for disease treatment. This workshop will give an overview of the emerging key roles of autocrine complement activity in the regulation of Th1 responses and then invites discussion about their implications for design of next generation therapeutics and monitoring.

 

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10:00 AM - 10:45 AM
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IntelliCyt offers an integrated solution that enables simultaneous screening of cells and secreted proteins in suspension for maximum insight into complex biology. Our iQue Screener platform is a benchtop instrument, software, and reagent system that optimizes the entire workflow to deliver the fastest time to results. Use of the lowest volume assays provides rich and insightful data in minutes. Two end-users will highlight how IntelliCyt’s high throughput approach to assay phenotypic endpoints  enabled them to identify compounds for myeloid differentiation and large scale anti-myeloma drug screening.

 

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10:00 AM - 10:45 AM
EXHIBITOR WORKSHOP ROOM 1
Abcam

Presenter:

Optimization strategies for ELISA and multiplex immunoassays to achieve sensitive, specific and accurate quantification of biomarkers will be discussed. These strategies are critical for the use of assays in research and also in assay development.  Many commercial assay kits perform with high sensitivity and a broad dynamic range using purified proteins but fail to perform in experimental sample types. Development of robust assays using matched antibody pairs can fail if the right steps are not taken. Strategies that will be discussed, include how to: titrate antibody pairs to improve signal to noise, formulate diluents to alleviate matrix effects, calibrate protein standards and validate for antibody pair cross-reactivity. Key fundamentals for use of ELISA and multiplex immunoassays will also be addressed, including how to  optimize sample dilutions based on your sample type, control for matrix effects, normalize for batch variability, and test for recovery and linearity of dilution.

 

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Accelerating Innovation with Immunosequencing

1:45 PM - 2:30 PM
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The immunoSEQ® Platform combines bias-controlled multiplex PCR with high-throughput sequencing and state-of the-art bioinformatics, delivering an accurate, quantitative profile of T- and B-cell receptors. Dr. Sanders will share case studies illustrating a variety of applications and get you thinking about how this new window into the clonality and diversity of the lymphocyte population will advance your research.

 

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Molecular Profiling of Tumor Microenvironment Using CancerNet Targeted NGS Panel

12:30 PM - 1:15 PM
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Presenters:

The clinical importance of tumor immune infiltrates has been an emerging area, particularly in triple negative breast cancer (TNBC) where increased immune infiltrate predicts both response to chemotherapy and improved survival. To this end, we have developed CancerNet, a comprehensive targeted RNA-Seq cancer immuno-panel that profiles ~2,000 genes and distinguishes 37 human hematopoietic cell phenotypes (including naïve and memory B cells, seven T-cell types, dendritic cells, plasma cells, natural killer (NK) cells and myeloid subsets), genes involved in checkpoint blockade and immunotherapy biomarkers, immune cell activation, and canonical immune pathway genes. The assay panel characterizes the cellular composition of the immune/stromal/cancer cell tumor microenvironment and determines the activation status of infiltrating immune cells in primary tumor tissues from TNBC patients. Preliminary data demonstrate the assay’s unparalleled specificity and sensitivity as well as an improved cost-effectiveness for high-throughput clinical Next-Gen applications.

 

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Leveraging 3D Biology for Development of Cancer Immuno-Oncology/Immuno-Therapy Biomarkers - Simultaneous Digital Counting of Nucleic-Acids and Proteins at 800-plex

12:30 PM - 1:15 PM
EXHIBITOR WORKSHOP ROOM 1
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Presenter:

The ability of mutated cells to give rise to cancer relies upon the ability to evade immune recognition, suppress immune activity, and persist in a chronically inflamed environment.  NanoString has developed an all-digital 3D technology for cancer immune-profiling by simultaneously measuring 770 mRNAs (from 24 infiltrating immune cell types plus numerous immune-signaling pathways) plus 60 key immune system-associated proteins (cell surface markers, immune checkpoints, cytokines, chemokines, etc.) in small amounts of clinically relevant samples.  This technology forms the basis for multi-year collaborations between NanoString and MD Anderson Cancer Center and the Cancer Immunotherapy Trials Network (CITN) to discover multi-analyte-type (mRNA + protein) biomarker signatures to guide cancer immunotherapy.  In this session, NanoString will present hidden biological information locked in DNA, RNA and protein.

 

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Quantitation of MHCII Trafficking Using Imaging in Flow

10:00 AM - 10:45 AM
EXHIBITOR WORKSHOP ROOM 2
MilliporeSigma

Presenters:

Imaging flow cytometry applies the speed, sensitivity, and phenotyping abilities of flow cytometry with the detailed imagery and functional insights of microscopy to address complex inquiries in immunology.  In this workshop, you will learn how Amnis® imaging flow cytometers have been used to examine the trafficking of MHC class II (MHCII) in dendritic cells.  The abundance of antigenic peptide-MHCII complexes on antigen presenting cells is determined by many factors that include the balance between the expression of newly generated complexes, complex internalization and subsequent re-emergence or degradation.  However, the molecular mechanisms that govern these interactions are still poorly understood.  Here, we discuss how multispectral imaging in flow can be used to visualize MHCII trafficking and elucidate the molecular mechanisms that regulate MHCII homeostasis in primary mouse and human dendritic cells.

 

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Multiplex-microarray Immunoassays and the Serological Confirmation of Chagas Disease

10:00 AM - 10:45 AM
EXHIBITOR WORKSHOP ROOM 1
SCIENION US, Inc. and InfYnity Biomarkers

Presenters:

Immunoassays are usually performed in 96-well plates, with
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The Role of Flow Cytometry in an Advanced Era of Immuno-Therapeutic Discovery

1:45 PM - 2:30 PM
EXHIBITOR WORKSHOP ROOM 2
Miltenyi Biotec

Presenter:

Progress in harnessing the power of the immune system is ushering in a new era of immunotherapy. A better understanding of the immune response and advancements in the manufacture of genetically-modified immune cells have been critical drivers of this progress. The discovery of effective translational findings relies strongly on robust and reproducible characterization of the cells that mediate the immunological response. Flow cytometry provides an effective methodology for this  characterization although the standardization of the process can be a challenging endeavor. This session will demonstrate usage of an innovative platform and reagents from Miltenyi Biotec in the exciting and groundbreaking work from two labs that illustrate the utility of flow cytometry for effective cellular characterization utilizing the innovative platform and reagents available from Miltenyi Biotec.

 

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Time to GoInVivo™: Validated Checkpoint Functional Antibodies for Cancer Research

1:45 PM - 2:30 PM
EXHIBITOR WORKSHOP ROOM 1
BioLegend

Presenter:

The immune system plays an essential role in controlling tumor growth. Tumor cells can communicate with immune checkpoint receptors to trick the response into suppression, allowing the tumor cell to grow without immune cell intervention. To interfere with this process, bioactive antibodies can deplete targeted immune cell populations or block important checkpoint interactions. Well-studied combinations include PD-1/PD-L1, CTLA-4/CD80 and CD86, LAG-3/MHC II, and Tim-3/Galectin 9. BioLegend’s GoInVivo™ antibodies against immune checkpoint molecules offer several advantages. They have been validated in both flow cytometry and in vitro bioassays, are pathogen-free as tested by qPCR, and have excellent pricing for large sizes. Here we present our portfolio, validation methods, as well as in vitro and in vivo applications. Specificity is characterized via flow cytometry staining and blocking capacity via target-ligand inhibition bioassays.  The effect of in vitro stimulation and in vivo injection on the activation phenotype and percentage of lymphocytes, as well as the cytokine profile are shown.

 

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Development of Immunotherapy Potency Assays Using Real-Time Cell Analysis and Flow Cytometry

12:30 PM - 1:15 PM
EXHIBITOR WORKSHOP ROOM 2
ACEA Biosciences, Inc.

Presenters:

Immunotherapy is one of the most promising approaches in cancer treatment, allowing specific elimination of cancer cells through activation of the immune response. However, despite the necessity of in vitro characterization of efficacy and potency of reagents and protocols before moving to more expensive animal models and clinical studies, current in vitro assays are difficult to implement in a high throughput environment, are not very quantitative and are based mainly on end point methods that are unable to capture the full dynamics of the immune response. In this workshop we will present a complete workflow that combines the power of xCELLigence real-time cell analysis together with the NovoCyte flow cytometer for a comprehensive effector-mediated potency assay.  We will show the validation conducted with antibodies and effector cells such as NK, CTLs, and CART on both solid and liquid tumor cell lines. Furthermore, we will also present data that demonstrates how this system could be used for evaluating antibodies in ADCC assays, Bi-specific T cell engagers, and checkpoint inhibitors.

 

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Massively-Parallel Sequencing for Immunology and Complex Disease: A Systems Biology Approach with RNA-Seq and Other Methods

12:30 PM - 1:15 PM
EXHIBITOR WORKSHOP ROOM 1
Illumina, Inc.

Presenter:

The use of next-generation sequencing and epigenetics in biological research can provide unique insights into the mechanisms and pathways of complex, multifactorial diseases. To take full advantage of the increasing capabilities of massively parallel sequencing, a holistic approach is needed. The ability to probe the genomics space from multiple perspectives, including targeted sequencing, transcriptomics, and epigenetics, unlocks new insights into the molecular mechanisms of disease. With a single sequencing platform, each of these genomics areas can be explored and combined to advance our understanding of complex disease. This workshop will provide you with an introduction to next-generation sequencing technology and to the many applications that are possible using next-generation sequencing. Learn about the sample to answer solutions to many different applications that Illumina offers. Join us for what is sure to be an interesting session!

 

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Cell-based Assays for T cell Metabolism: Understanding the Drivers of Immunity

11:15 AM - 12:00 PM
EXHIBITOR WORKSHOP ROOM 2
Seahorse Bioscience

Presenters:

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Advancements in Immunotherapeutic Research with Magnetic Cell Separation

11:15 AM - 12:00 PM
EXHIBITOR WORKSHOP ROOM 1
Miltenyi Biotec

Presenter:

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Multiplex Assays of Fifteen Human Complement Factors Using New MILLIPLEX® map Panels

10:00 AM - 10:45 AM
EXHIBITOR WORKSHOP ROOM 2
MilliporeSigma

Presenter:

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Considerations in Determining Targets for Cancer Immunotherapy

10:00 AM - 10:45 AM
EXHIBITOR WORKSHOP ROOM 1
MilliporeSigma

Presenters:

Antibodies have gained importance as powerful therapeutic armamentarium for a wide range of human diseases, including many types of cancer. Cancer immunotherapy offers advantages of high specificity, fewer side effects, and long-term benefits in some patients. However, it also creates challenges because subtle changes that make cancer cells immortal are not sufficient enough to elicit an immune reaction. Although the number of therapeutic options are growing, monoclonal antibodies offer a clear advantage of specificity and shorter life-span, which limits undesirable side effects. However, there is still need to understand target pathways and develop validated antibodies for research use to first reveal appropriately differentiated targets.  This presentation will discuss some new research antibodies developed by MilliporeSigma to key tumor specific antigens that may be valuable in identifying novel cancer pathway targets.

 

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 SOLD!  Mobile App Rotating Banner Ad - $1,000

Rotating banner sponsors receive a clickable banner ad displayed at the top of the home page. Ads will also be displayed and rotating on the desktop version.

[su_button url="http://aai.org/Meetings/Future/Docs/web/2016_PrelExhPros.html" target="new_blank" style="flat" background="#A7A038" color="#ffffff" size="5" icon_color="#ffffff" text_shadow="0px 0px 0px #ffffff" class="button-w-padding"]See Exhibitor Prospectus[/su_button]

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Opening Night Welcome - $10,000 (per shared sponsorship)

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Purchase See Exhibitor Prospectus

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Grants and Awards

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Career Sessions

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Lectures Symposia

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 SOLD!  Banners - $1,500 each

4’x8’ banners located at the top of two sets of escalators leading to the Exhibit Hall and Scientific Program meeting rooms. Opportunities are available for four banners at the 4th floor and four banners at the 3rd floor. Banners will be viewed as attendees reach the top of the escalators. Limit, two banners per sponsor.

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 SOLD!  Hotel Key Cards - $10,000

Reach attendees numerous times daily with an exclusive sponsorship of hotel key cards. Your company message will be printed on the room key provided to attendees staying in the AAI hotel block. Logo and graphics must be submitted to AAI for pre-approval and we will arrange for production and delivery. Qualifies for Supporting Sponsor.

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 SOLD!  Lanyards - $5,000

Attendees will display your company name around their necks. Sponsor arranges for production and delivery of at least 3,500 lanyards. Qualifies for Contributing Sponsor.

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 SOLD!  Meeting Bags - $25,000

See attendees carrying your logo to work, on shopping trips and more! AAI will arrange for production and delivery of at least 3,500 bags. Qualifies for Silver Sponsor.

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Attendee Mailing List

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Exhibit Hall Only Day Pass - $50 each

Invite your clients in the local Seattle metropolitan area to come to your booth during show hours on Monday, May 16. Your guests’ badges will provide access that day for entry into the Exhibit Hall to visit with you (non-refundable and non-transferable; access to Exhibit Hall only. These will be available for purchase when IMMUNOLOGY 2016TM registration opens in December 2015.

Purchase See Exhibitor Prospectus

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 SOLD!  Passport Program

AAI offers this program to drive traffic to your booth. Participate so that your company's booth will be featured on a special map of the Exhibit Hall floor and the IMMUNOLOGY 2016™ Passport placed in every attendee's Meeting Bag. You'll be able to visit with the many attendees coming to your booth to obtain your stamp on their maps. Attendees enter their completed Passports into the drawings for one of three $250 American Express gift cards. The drawing will be held during the Poster Presentation Hour on Monday. This program is limited to exhibitors with 200 square feet booths or less. (Stamps will be provided by AAI.) Limit, 16 sponsors.

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 SOLD!  Mobile App - $8,000

The app was used by 64% of 2015 conference attendees. Elite sponsor will have their logo on the splash screen, a clickable rotating banner ad, and booth highlighted on the exhibit hall floor plan in the app. Rotating Banner Sponsors receive a clickable banner ad displayed at the top of the home page. Ads will also be displayed and rotated on the desktop version. Up to 6 Rotating Banner ads are available. Elite Sponsor Qualifies for Supporting Sponsor.

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 SOLD!  Coffee Break - $6,000

Host coffee for the attendees in the Expo Hall on either Saturday, Sunday, or Monday, including a coffee station in your booth as well as coffee service located in the Exhibit Hall. Sponsor is invited to supply branded cups and napkins for the event. Qualifies for Supporting Sponsor.

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 SOLD!  Stair Decals - $5,000

stair_decalsPromote your message to attendees using stair decals located right inside the entrance to the Washington State Convention Center. Each attendee will walk those stairs to get to the Exhibit Hall and Scientific Sessions. There are two sets of stairs (seven stairs each) available; decals will be 10’ in length. Qualifies for Contributing Sponsor for one set of stairs and Supporting Sponsor for both sets.

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Hotel In-Room Promotional Material Drop - $8,000

Entice attendees by delivering any of a variety of branded items (small box of chocolate, local Seattle treat, etc) or a marketing piece (postcard, invitation to your booth, your company’s marketing item, etc) to each attendee in the AAI hotel block. Limit one drop per evening on Friday, Saturday, and Sunday evenings. Sponsor to arrange delivery of materials to all AAI hotels. Size restrictions may apply and items must be submitted to AAI for approval no later than 30 days prior to the meeting. Limit, one drop per evening. Qualifies for Supporting Sponsor.

Purchase See Exhibitor Prospectus

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 SOLD!  Power/Charging Station - $3,000

power charging stationToday's attendees travel with at least one mobile device, whether it is a smartphone, tablet, or laptop. Create excitement around your company's product/service offering. Sponsorship includes charging station branded with sponsor logo. Limit, 1 sponsor. Qualifies for Contributing Sponsor.      

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 SOLD!  Escalator Runners - $3,000 each

escalatorThree sets of escalators take attendees from entrance to the Center on street level up to the Expo Hall on Level 4. Each set of escalators has one up, one down, and one in the middle determined by traffic flow. Two runner spots available for each set of escalators. Sponsor two and save. Limit six total, two runners per sponsor. Qualifies for Contributing Sponsor.

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 SOLD!  Meeting Bag Insert - $3,000 each

Place your promotional materials or item right into all attendees' hands for long-term residual exposure. Sponsor arranges purchase, production, and delivery of at least 3,500 items. Limitations on size apply and items must be submitted to AAI for approval. Examples of acceptable inserts are: promotional brochures, postcards, other printed materials (no catalogs), pens, note pads, USB flash drives, water bottles, luggage tags, umbrellas, laser pointers. Limit, 6 sponsors. Qualifies for Contributing Sponsor.

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 SOLD!  Exhibitor Workshop $1,000 each

This popular opportunity is available in one of two rooms on the Exhibit Hall floor. With theater-style seating for up to 100 attendees, each room provides the perfect setting for in-depth presentations and discussions. Workshops cannot conflict with the daily poster presentations time.  Presentation topic, date, time, and description will be included in the meeting Program. Note: The one-hour room includes time needed for your set-up, 45-minute presentation, and tear down time. Limit, 24 workshops.

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Exhibit Hall Aisle Banners $500 each

Attendees refer to the large aisle signs overhead to get their bearings in the Exhibit Hall. Add your name/logo and booth number on your aisle sign to reach all attendees who visit the Exhibit Hall. Aisle Banners will feature 4'x3' sponsor branding and booth number on every sign. Limit, 11 sponsors.

Purchase See Exhibitor Prospectus

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