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Post-doctoral Research Fellow – Dormancy/Immunology

Fred Hutchinson Cancer Research Center
Seattle, WA

Fred Hutchinson Cancer Research Center’s Laboratory for the Study of Metastatic Microenvironments (LSM2), directed by Dr. Cyrus Ghajar, is looking for a talented post-doctoral fellow with extensive expertise in the realm of tumor immunology. The LSM2 focuses on understanding the biology underlying disseminated tumor cell (DTC) dormancy (see Ghajar et al., Nature Cell Biology 2013 and Ghajar, Nature Reviews Cancer 2015) and uncovering means to eradicate dormant DTCs.

The candidate will spearhead a project with the following goals:

  1. to understand how the perivascular niche steers immune cell phenotype, and
  2. to determine whether an immunotherapy-based strategy to target dormant DTCs is feasible. The ideal candidate will be interested and able to develop his/her own research strategy to understand DTC-immune cell interactions by utilizing an array of innovative models and sophisticated techniques we have developed or adopted in the lab. These include three-dimensional cell culture models, murine metastasis models and intravital imaging approaches.

Qualifications
A Ph.D. in the field of immunology, tumor immunology, or closely related field (with strong expertise in tumor immunology) is required. A strong publication record and eligibility and desire to apply for future fellowships are also required. The candidate must also be experienced in essential techniques to characterize and profile immune cells and to gauge their function. A candidate with experience in live cell imaging, developing quantitative image analysis approaches, and experience working in murine tumor or metastasis models is strongly desired.

The successful candidate must have excellent communication and organizational skills, the ability to develop creative approaches to experimental design, and thrive both in independent research and while working collaboratively with other fellows and graduate students in the lab.

For more information, and to apply, please visit http://www.fredhutch.org/job/5693. Inquiries can also be sent to Dr. Jessica Huszar at jhuszar@fredhutch.org.

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Important Dates

  • Abstracts

    Deadline to Request Edits to Abstracts March 1, 2016
    Abstract Acceptance & Schedule March 11, 2016

  • Travel Awards

    Travel Award Notifications March 11, 2016

  • Registration

    Registration Opens December 16, 2015
    Early Registration Deadline March 30, 2016
    Late Registration Deadline May 12, 2016

  • Housing

    Deadline for Discounted Rates April 22, 2016

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EXHIBITOR WORKSHOP ROOM 2
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Presenter:

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1:45 PM - 2:30 PM
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Presenter:

Multilaser flow cytometers with the capacity for simultaneous measurement of sufficient targets for immunological analysis
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Fast and Easy Isolation of Highly Pure Unique Immune Cell Subsets Using EasySep™ Release

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Presenters:

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11:15 AM - 12:00 PM
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MilliporeSigma

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Accelerating Immuno-oncology and Antibody Discovery Research Through Large Scale Profiling of Suspension Cells Using the iQue Screener Platform

10:00 AM - 10:45 AM
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Presenters:

IntelliCyt offers an integrated solution that enables simultaneous screening of cells and secreted proteins in suspension for maximum insight into complex biology. Our iQue Screener platform is a benchtop instrument, software, and reagent system that optimizes the entire workflow to deliver the fastest time to results. Use of the lowest volume assays provides rich and insightful data in minutes. Two end-users will highlight how IntelliCyt’s high throughput approach to assay phenotypic endpoints  enabled them to identify compounds for myeloid differentiation and large scale anti-myeloma drug screening.

 

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EXHIBITOR WORKSHOP ROOM 1
Abcam

Presenter:

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Presenter:

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Molecular Profiling of Tumor Microenvironment Using CancerNet Targeted NGS Panel

12:30 PM - 1:15 PM
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Presenters:

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Leveraging 3D Biology for Development of Cancer Immuno-Oncology/Immuno-Therapy Biomarkers - Simultaneous Digital Counting of Nucleic-Acids and Proteins at 800-plex

12:30 PM - 1:15 PM
EXHIBITOR WORKSHOP ROOM 1
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Presenter:

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Quantitation of MHCII Trafficking Using Imaging in Flow

10:00 AM - 10:45 AM
EXHIBITOR WORKSHOP ROOM 2
MilliporeSigma

Presenters:

Imaging flow cytometry applies the speed, sensitivity, and phenotyping abilities of flow cytometry with the detailed imagery and functional insights of microscopy to address complex inquiries in immunology.  In this workshop, you will learn how Amnis® imaging flow cytometers have been used to examine the trafficking of MHC class II (MHCII) in dendritic cells.  The abundance of antigenic peptide-MHCII complexes on antigen presenting cells is determined by many factors that include the balance between the expression of newly generated complexes, complex internalization and subsequent re-emergence or degradation.  However, the molecular mechanisms that govern these interactions are still poorly understood.  Here, we discuss how multispectral imaging in flow can be used to visualize MHCII trafficking and elucidate the molecular mechanisms that regulate MHCII homeostasis in primary mouse and human dendritic cells.

 

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Multiplex-microarray Immunoassays and the Serological Confirmation of Chagas Disease

10:00 AM - 10:45 AM
EXHIBITOR WORKSHOP ROOM 1
SCIENION US, Inc. and InfYnity Biomarkers

Presenters:

Immunoassays are usually performed in 96-well plates, with
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The Role of Flow Cytometry in an Advanced Era of Immuno-Therapeutic Discovery

1:45 PM - 2:30 PM
EXHIBITOR WORKSHOP ROOM 2
Miltenyi Biotec

Presenter:

Progress in harnessing the power of the immune system is ushering in a new era of immunotherapy. A better understanding of the immune response and advancements in the manufacture of genetically-modified immune cells have been critical drivers of this progress. The discovery of effective translational findings relies strongly on robust and reproducible characterization of the cells that mediate the immunological response. Flow cytometry provides an effective methodology for this  characterization although the standardization of the process can be a challenging endeavor. This session will demonstrate usage of an innovative platform and reagents from Miltenyi Biotec in the exciting and groundbreaking work from two labs that illustrate the utility of flow cytometry for effective cellular characterization utilizing the innovative platform and reagents available from Miltenyi Biotec.

 

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Time to GoInVivo™: Validated Checkpoint Functional Antibodies for Cancer Research

1:45 PM - 2:30 PM
EXHIBITOR WORKSHOP ROOM 1
BioLegend

Presenter:

The immune system plays an essential role in controlling tumor growth. Tumor cells can communicate with immune checkpoint receptors to trick the response into suppression, allowing the tumor cell to grow without immune cell intervention. To interfere with this process, bioactive antibodies can deplete targeted immune cell populations or block important checkpoint interactions. Well-studied combinations include PD-1/PD-L1, CTLA-4/CD80 and CD86, LAG-3/MHC II, and Tim-3/Galectin 9. BioLegend’s GoInVivo™ antibodies against immune checkpoint molecules offer several advantages. They have been validated in both flow cytometry and in vitro bioassays, are pathogen-free as tested by qPCR, and have excellent pricing for large sizes. Here we present our portfolio, validation methods, as well as in vitro and in vivo applications. Specificity is characterized via flow cytometry staining and blocking capacity via target-ligand inhibition bioassays.  The effect of in vitro stimulation and in vivo injection on the activation phenotype and percentage of lymphocytes, as well as the cytokine profile are shown.

 

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Development of Immunotherapy Potency Assays Using Real-Time Cell Analysis and Flow Cytometry

12:30 PM - 1:15 PM
EXHIBITOR WORKSHOP ROOM 2
ACEA Biosciences, Inc.

Presenters:

Immunotherapy is one of the most promising approaches in cancer treatment, allowing specific elimination of cancer cells through activation of the immune response. However, despite the necessity of in vitro characterization of efficacy and potency of reagents and protocols before moving to more expensive animal models and clinical studies, current in vitro assays are difficult to implement in a high throughput environment, are not very quantitative and are based mainly on end point methods that are unable to capture the full dynamics of the immune response. In this workshop we will present a complete workflow that combines the power of xCELLigence real-time cell analysis together with the NovoCyte flow cytometer for a comprehensive effector-mediated potency assay.  We will show the validation conducted with antibodies and effector cells such as NK, CTLs, and CART on both solid and liquid tumor cell lines. Furthermore, we will also present data that demonstrates how this system could be used for evaluating antibodies in ADCC assays, Bi-specific T cell engagers, and checkpoint inhibitors.

 

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Massively-Parallel Sequencing for Immunology and Complex Disease: A Systems Biology Approach with RNA-Seq and Other Methods

12:30 PM - 1:15 PM
EXHIBITOR WORKSHOP ROOM 1
Illumina, Inc.

Presenter:

The use of next-generation sequencing and epigenetics in biological research can provide unique insights into the mechanisms and pathways of complex, multifactorial diseases. To take full advantage of the increasing capabilities of massively parallel sequencing, a holistic approach is needed. The ability to probe the genomics space from multiple perspectives, including targeted sequencing, transcriptomics, and epigenetics, unlocks new insights into the molecular mechanisms of disease. With a single sequencing platform, each of these genomics areas can be explored and combined to advance our understanding of complex disease. This workshop will provide you with an introduction to next-generation sequencing technology and to the many applications that are possible using next-generation sequencing. Learn about the sample to answer solutions to many different applications that Illumina offers. Join us for what is sure to be an interesting session!

 

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Cell-based Assays for T cell Metabolism: Understanding the Drivers of Immunity

11:15 AM - 12:00 PM
EXHIBITOR WORKSHOP ROOM 2
Seahorse Bioscience

Presenters:

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Advancements in Immunotherapeutic Research with Magnetic Cell Separation

11:15 AM - 12:00 PM
EXHIBITOR WORKSHOP ROOM 1
Miltenyi Biotec

Presenter:

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10:00 AM - 10:45 AM
EXHIBITOR WORKSHOP ROOM 2
MilliporeSigma

Presenter:

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Considerations in Determining Targets for Cancer Immunotherapy

10:00 AM - 10:45 AM
EXHIBITOR WORKSHOP ROOM 1
MilliporeSigma

Presenters:

Antibodies have gained importance as powerful therapeutic armamentarium for a wide range of human diseases, including many types of cancer. Cancer immunotherapy offers advantages of high specificity, fewer side effects, and long-term benefits in some patients. However, it also creates challenges because subtle changes that make cancer cells immortal are not sufficient enough to elicit an immune reaction. Although the number of therapeutic options are growing, monoclonal antibodies offer a clear advantage of specificity and shorter life-span, which limits undesirable side effects. However, there is still need to understand target pathways and develop validated antibodies for research use to first reveal appropriately differentiated targets.  This presentation will discuss some new research antibodies developed by MilliporeSigma to key tumor specific antigens that may be valuable in identifying novel cancer pathway targets.

 

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 SOLD!  Mobile App Rotating Banner Ad - $1,000

Rotating banner sponsors receive a clickable banner ad displayed at the top of the home page. Ads will also be displayed and rotating on the desktop version.

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Opening Night Welcome - $10,000 (per shared sponsorship)

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Purchase See Exhibitor Prospectus

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Grants and Awards

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Career Sessions

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Lectures Symposia

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 SOLD!  Banners - $1,500 each

4’x8’ banners located at the top of two sets of escalators leading to the Exhibit Hall and Scientific Program meeting rooms. Opportunities are available for four banners at the 4th floor and four banners at the 3rd floor. Banners will be viewed as attendees reach the top of the escalators. Limit, two banners per sponsor.

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 SOLD!  Hotel Key Cards - $10,000

Reach attendees numerous times daily with an exclusive sponsorship of hotel key cards. Your company message will be printed on the room key provided to attendees staying in the AAI hotel block. Logo and graphics must be submitted to AAI for pre-approval and we will arrange for production and delivery. Qualifies for Supporting Sponsor.

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 SOLD!  Lanyards - $5,000

Attendees will display your company name around their necks. Sponsor arranges for production and delivery of at least 3,500 lanyards. Qualifies for Contributing Sponsor.

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 SOLD!  Meeting Bags - $25,000

See attendees carrying your logo to work, on shopping trips and more! AAI will arrange for production and delivery of at least 3,500 bags. Qualifies for Silver Sponsor.

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Attendee Mailing List

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Exhibit Hall Only Day Pass - $50 each

Invite your clients in the local Seattle metropolitan area to come to your booth during show hours on Monday, May 16. Your guests’ badges will provide access that day for entry into the Exhibit Hall to visit with you (non-refundable and non-transferable; access to Exhibit Hall only. These will be available for purchase when IMMUNOLOGY 2016TM registration opens in December 2015.

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 SOLD!  Passport Program

AAI offers this program to drive traffic to your booth. Participate so that your company's booth will be featured on a special map of the Exhibit Hall floor and the IMMUNOLOGY 2016™ Passport placed in every attendee's Meeting Bag. You'll be able to visit with the many attendees coming to your booth to obtain your stamp on their maps. Attendees enter their completed Passports into the drawings for one of three $250 American Express gift cards. The drawing will be held during the Poster Presentation Hour on Monday. This program is limited to exhibitors with 200 square feet booths or less. (Stamps will be provided by AAI.) Limit, 16 sponsors.

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 SOLD!  Mobile App - $8,000

The app was used by 64% of 2015 conference attendees. Elite sponsor will have their logo on the splash screen, a clickable rotating banner ad, and booth highlighted on the exhibit hall floor plan in the app. Rotating Banner Sponsors receive a clickable banner ad displayed at the top of the home page. Ads will also be displayed and rotated on the desktop version. Up to 6 Rotating Banner ads are available. Elite Sponsor Qualifies for Supporting Sponsor.

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 SOLD!  Coffee Break - $6,000

Host coffee for the attendees in the Expo Hall on either Saturday, Sunday, or Monday, including a coffee station in your booth as well as coffee service located in the Exhibit Hall. Sponsor is invited to supply branded cups and napkins for the event. Qualifies for Supporting Sponsor.

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 SOLD!  Stair Decals - $5,000

stair_decalsPromote your message to attendees using stair decals located right inside the entrance to the Washington State Convention Center. Each attendee will walk those stairs to get to the Exhibit Hall and Scientific Sessions. There are two sets of stairs (seven stairs each) available; decals will be 10’ in length. Qualifies for Contributing Sponsor for one set of stairs and Supporting Sponsor for both sets.

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Hotel In-Room Promotional Material Drop - $8,000

Entice attendees by delivering any of a variety of branded items (small box of chocolate, local Seattle treat, etc) or a marketing piece (postcard, invitation to your booth, your company’s marketing item, etc) to each attendee in the AAI hotel block. Limit one drop per evening on Friday, Saturday, and Sunday evenings. Sponsor to arrange delivery of materials to all AAI hotels. Size restrictions may apply and items must be submitted to AAI for approval no later than 30 days prior to the meeting. Limit, one drop per evening. Qualifies for Supporting Sponsor.

Purchase See Exhibitor Prospectus

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 SOLD!  Power/Charging Station - $3,000

power charging stationToday's attendees travel with at least one mobile device, whether it is a smartphone, tablet, or laptop. Create excitement around your company's product/service offering. Sponsorship includes charging station branded with sponsor logo. Limit, 1 sponsor. Qualifies for Contributing Sponsor.      

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 SOLD!  Escalator Runners - $3,000 each

escalatorThree sets of escalators take attendees from entrance to the Center on street level up to the Expo Hall on Level 4. Each set of escalators has one up, one down, and one in the middle determined by traffic flow. Two runner spots available for each set of escalators. Sponsor two and save. Limit six total, two runners per sponsor. Qualifies for Contributing Sponsor.

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 SOLD!  Meeting Bag Insert - $3,000 each

Place your promotional materials or item right into all attendees' hands for long-term residual exposure. Sponsor arranges purchase, production, and delivery of at least 3,500 items. Limitations on size apply and items must be submitted to AAI for approval. Examples of acceptable inserts are: promotional brochures, postcards, other printed materials (no catalogs), pens, note pads, USB flash drives, water bottles, luggage tags, umbrellas, laser pointers. Limit, 6 sponsors. Qualifies for Contributing Sponsor.

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 SOLD!  Exhibitor Workshop $1,000 each

This popular opportunity is available in one of two rooms on the Exhibit Hall floor. With theater-style seating for up to 100 attendees, each room provides the perfect setting for in-depth presentations and discussions. Workshops cannot conflict with the daily poster presentations time.  Presentation topic, date, time, and description will be included in the meeting Program. Note: The one-hour room includes time needed for your set-up, 45-minute presentation, and tear down time. Limit, 24 workshops.

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Exhibit Hall Aisle Banners $500 each

Attendees refer to the large aisle signs overhead to get their bearings in the Exhibit Hall. Add your name/logo and booth number on your aisle sign to reach all attendees who visit the Exhibit Hall. Aisle Banners will feature 4'x3' sponsor branding and booth number on every sign. Limit, 11 sponsors.

Purchase See Exhibitor Prospectus

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